Master Student in Magnetic Bioprinting

vor 2 Wochen

Wien, Wien, Österreich CeMM Vollzeit
Master Student in Magnetic Bioprinting (m/f/d)

We are recruiting an ambitious master thesis student who wants to pursue groundbreaking research in the areas of bioengineering. It will be based in the laboratory of Abdel Rahman Abdel Fattah at CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences in Vienna.

The Project

Organoid research has revolutionized our ability to model human tissue in vitro, but variability between organoids often limits their reproducibility and the complexity of biological phenomena they can recapitulate. This project introduces a novel bioprinting approach to enhance cortical organoid (CO) organization using a high-throughput, label-free, and nozzle-free magnetic bioprinting technique. By depositing differentiated human pluripotent stem cells (hPSCs) layer-by-layer, we aim to construct COs with pre-defined cortical layers. This bioprinting approach seeks to reduce organoid variability by controlling initial cellular organization, offering an innovative alternative to traditional self-organization methods.

We will optimize magnetic field geometries and cell magnetophoresis through simulations with COMSOL and Matlab. We will build a magnetic platform using in-house 3D-printers, generate magnetic fields using N52 neodymium magnets, and synthesize paramagnetic media using gadopentetic acid. Using differentiated hPSC-reporter lines, we will generate PAX6+, TBR1+, CTIP2+ and SATB2+ cells, which we will bioprint in a multilayered fashion to form our organoids. We will use entropy-based metrics to quantify tissue organization and study the organoids' ability to maintain spatial order. Our project will also assess the transcriptomic landscape of bioprinted organoids using single-cell RNA sequencing, shedding light on molecular players that improve tissue organization.

Your Profile

We are seeking a motivated and talented Master's student with a strong background in bioengineering, cell biology, or related fields. Experience in cell culture techniques is essential, and familiarity with organoid culture, matrices and/or hydrogels, microscopy, or computational modeling is highly desirable. You will have the opportunity to contribute to cutting-edge research in a highly collaborative environment (working closely with a Postdoc) and gain expertise in bioprinting, organoid technologies, and transcriptomic analysis. The project requires a commitment of 6–12 months, with the potential for co-authorship in a high-impact publication.

The Abdel Fattah Lab

Our lab exists at the interface of engineering and biology and we are driven by the question: how do cells use the extracellular matrix and mechanical forces to collectively coordinate, initiate, and maintain tissue organization, and what happens when forces are too much to handle? We particularly focus on how local mechanical conditions instruct tissue organization through global morphological and cell state changes, but also tissue disorganization in conditions such as liver fibrosis and traumatic brain injuries. We take three approaches to address this:

  1. We engineer our own platforms to mechanically stimulate and measure local and emerging mechanical properties in tissues.
  2. We explore mechanobiology across the scales in-vitro, going from multicellular events to molecular drivers, in order to characterize and study the dynamic relationship between cells and their extracellular matrix (ECM) microenvironment.
  3. We develop computational models to explore the physical laws and logic used by cells to organize, in our effort to establish the mechanical roadmap to tissue organization.

Our main research topics include central nervous system health, traumatic brain and spinal cord injuries, and liver fibrosis. We utilize several in-vitro model systems, with a primary focus on those derived from human pluripotent stem cells.

The Principal Investigator

Abdel Rahman Abdel Fattah joined CeMM in 2022 as a Postdoc in the Lab of Giulio Superti-Furga where he focused on the metabolic dimension of fate mechanoregulation. In 2024, Abdel became a Principal Investigator at CeMM. He studied Mechanical Engineering at McMaster University (Canada) and gained industry experience in the renewable energy industry in Ontario. He then returned to McMaster University to complete his Ph.D. in the laboratory of Prof. Ishwar K. Puri, where he combined magnetic and fluid dynamics theories to manipulate synthetic and biological materials, fabricate mechanically anisotropic polymers, print carbon-nanotube biosensors, and bioprint 3D cellular constructs for tissue engineering applications. For his postdoctoral studies, Abdel joined the Lab of Morphogenesis and Bioengineering at KU Leuven (Belgium) under the mentorship of Prof. Adrian Ranga.

About the Institute

CeMM is an international research institute of the Austrian Academy of Sciences and a founding member of EU-LIFE. The mission of CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences is to achieve maximum scientific innovation in molecular medicine to improve healthcare. At CeMM, an international and creative team of scientists and medical doctors pursues free-minded basic life science research in a large and vibrant hospital environment of outstanding medical tradition and practice. CeMM's research is based on post-genomic technologies and focuses on societally important diseases, such as immune disorders and infections, cancer, aging and metabolic disorders. CeMM operates in a unique mode of super-cooperation, connecting biology with medicine, experiments with computation, discovery with translation, and science with society and the arts.

We offer
  • Work within an experienced, interdisciplinary, and international team at one of Austria's leading research institutes.
  • Ample opportunities to contribute and gain experience in a key area of biomedical research and precision medicine.
  • An inspiring workplace with an international setting, strong team spirit, and an excellent work climate.
  • A wide range of social, cultural, and sports activities organized by the institute.
  • Excellent employee benefits including full insurance coverage (health, accident, retirement), health care services, subsidized cafeteria.
  • Monthly gross salary of EUR1.299,60 for 20 hours/week.
  • Support for relocating to Vienna is provided (relocation reimbursement, visa support, etc.).

Please apply online with cover letter, CV, certificates (high school & university Diploma/grades), and contact details of 2 referees. Any application received by Feb 25th 2025 will be considered.

Additional information

City: Vienna

Position type: Part-time employee

Start of work: 01.06.2025

Responsible

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