Laboratory Technician: Therapeutic Discovery in

vor 1 Woche

Wien, Wien, Österreich CeMM Vollzeit

We are looking for a highly motivated laboratory technician who is excited to work within an international consortium on the identification and development of novel therapeutic strategies for the treatment of childhood cancers.


Profile:

Typical tasks

Tasks and responsibilities contain, but are not limited to:

  • Cell Culture (maintenance, manipulation via genome engineering)
  • High throughput drug screens using our automated facility
  • Functional genomics including CRISPR/Cas9 screens and protein stability reporter screens
  • General molecular biology techniques (immunoblots, cloning, immunoprecipitations)
  • Technology development
  • Training of new lab members
  • Certain lab management responsibilities
The Winter Lab

We are an international and multi-disciplinary research lab. When you work with us, you will work in a team of molecular biologists, biochemists, and medicinal chemists. Through our international consortium, we also have access to medical doctors, clinical trial specialists and patient advocates.

Our mission is to connect that wide umbrella of backgrounds to reimagine the treatment of solid tumors in children by finding drugs that induce the degradation of well-known drivers of these diseases.

You'd be working with high-throughput technologies such as genome-wide CRISPR/Cas9 screens, phenotypic drug screen and proteomics. The setup in our group and in our consortium is interdisciplinary, diverse, and inclusive.

This fosters an environment that is required for the generation of innovate ideas and novel concepts that are needed to advance novel therapeutic strategies.

The Principal Investigator


Georg Winter obtained his PhD from the Medical University of Vienna, working on elucidating the mechanism of action of anti-neoplastic drugs under the supervision of Professor Giulio Superti-Furga at CeMM.

He specialized in proteomics as well as chemical genetic approaches to identifying drug resistance mechanisms and on mechanistically elucidating synergistic drug combinations.

He continued his training in chemical biology, working as a postdoctoral fellow with Dr. James Bradner at the Dana Farber Cancer Institute/Harvard Medical School.

There, he innovated a generalizable pharmacological solution to in vivo target protein degradation and applied this strategy to the study of leukemic gene regulation.

Georg Winter was recruited as CeMM principal investigator in June 2016.

His lab develops and applies methods for target protein degradation with the ultimate goal of understanding and disrupting oncogenic transcriptional circuits.

To that end, the Winter laboratory combines phenotypic drug screens, chemical genetics, and drug-target identification approaches with holistic measurements of global gene activity and genome structure.

The ultimate goal of the research conducted in the Winter laboratory is to connect basic research in gene regulation and the ubiquitin proteasome system with functional genomics and chemical probe development to develop novel and personalized therapeutic paradigms.

About the Institute

We offer

  • Work within an experienced, interdisciplinary, and international team at one of Austria's leading research institutes
  • Ample opportunities to contribute and gain experience in a key area of biomedical research and precision medicine
  • An inspiring workplace with an international setting, strong team spirit, and an excellent work climate
  • A wide range of social, cultural, and sports activities organized by the institute
  • Excellent employee benefits including full insurance coverage (health, accident, retirement), health care services, subsidized cafeteria
  • Minimum monthly gross salary of EUR 2.850,00 paid out 14 times yearly (following the recommendations of FWF).
  • Support for relocating to Vienna is provided (relocation reimbursement, visa support, etc.)

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