Computational Biology

vor 2 Wochen

Wien, Österreich CeMM Vollzeit

Do you want to be part of an interdisciplinary project, bringing together protein-protein interaction data of transmembrane proteins with the knowledge from protein structures and genetic variants using artificial intelligence and machine learning?

We are looking for a computational biology / bioinformatics scientist to mine, evaluate and analyze protein-protein interaction data on human membrane transporters as well as implement experimental structure data and AlphaFold models for predicting biomedical effects of genetic variants in human membrane transporters.

You will work in the Giulio Superti-Furga group (CeMM, Vienna) on the project “mlDIAMANT: machine learning decodes interaction archetypes of membrane proteins to predict the effect of genetic variants”. mlDIAMANT is a collaboration project with the Peter Sykacek group at BOKU, Vienna. You will be working closely with the two group leaders and postdoctoral and PhD student colleagues who will join the project, at CeMM and BOKU respectively.

Together we want to manifest the biomedical impact of human transporter research coupling state-of-the-art computational and experimental approaches.

**Profile**:

- PhD in bioinformatics, proteomics, structural biology or similar experience
- Experience in computational structural biology
- Knowledge of computational modelling and analysis of protein structures (e.g.: AlphaFold multimer models)
- Understanding of structural-evolutionary relationships (is beneficial)
- Solid understanding of basic statistics
- Interest in the structural principles of protein-protein interactions
- Interest to work in a multidisciplinary team at the interface of protein structural modelling, interaction proteomics and machine learning
- Strong data visualization skills is an asset
- Knowledge on advanced statistical approaches is an advantage
- Ability to work in a team and pursue goals in a focused way
- Excellent written / oral communication skills in English

The mlDIAMANT collaboration project

The Superti-Furga Lab

The Sykacek Lab

CeMM Research Center for Molecular Medicine

BOKU University of Natural Resources and Life Sciences

We offer
- Work within an experienced, interdisciplinary, and international team at one of Austria’s leading research institutes
- Ample opportunities to contribute and gain experience in a key area of biomedical research and precision medicine
- An inspiring workplace with an international setting, strong team spirit, and an excellent work climate
- A wide range of social, cultural, and sports activities organized by the institute
- Excellent employee benefits including full insurance coverage (health, accident, retirement), health care services, subsidized cafeteria
- Minimum monthly gross salary of EUR 4.752,30 for 40 hours paid out 14 times yearly (following the recommendations of FWF).
- Support for relocating to Vienna is provided (relocation reimbursement, visa support, etc.)

Application deadline is April 14th, 2024, and the starting date will be summer 2024.

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