Senior Scientist, Global Proteomics

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at Job Function : Discovery & Pre-Clinical / Clinical Development Job Sub Function : Biological Research Job Category : Scientific / Technology All Job Posting Locations : Cambridge, Massachusetts, United States of America Job Description About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. We are searching for the best talent for a Senior Scientist, Global Proteomics to be located in Cambridge, MA. Purpose: Do you want to use your hard-earned skills and drive to make a difference in the lives of patients? Join the growing Discovery Proteomic Platforms (DPP) group within the Discovery Technologies and Molecular Pharmacology (DTMP) department of Therapeutics Discovery to apply groundbreaking approaches to high-scale proteomic analysis. Be part of a motivated team deploying cutting-edge mass spectrometry technologies to tackle challenges in end to end drug discovery and development. Work across a leading multiomics organization to provide coordinated insights across a variety of 'omics layers. This is a hands‑on laboratory role with project leadership responsibilities‑fit for a scientist who thrives at the bench and also enjoys crafting experimental strategy, presenting results, and representing proteomics in cross‑functional project teams. With your help, we will drive development of medicines for our patients Responsibilities Join a team of wet lab scientists enabling proteomic impact across a wide variety of programs and therapeutic modalities. Plan and perform wet lab proteomic activities supporting evaluation of therapeutic candidates and drive SAR enabled risk mitigation of small molecules. Operate and maintain LC‑MS instrumentation (Thermo Orbitrap Exploris/Eclipse/Astral, Bruker timsTOF; LC systems such as Vanquish Neo, Evosep One, UltiMate) with full responsibility for daily/weekly maintenance, calibration, and troubleshooting. Deploy automation‑supported workflows for high‑throughput sample prep using platforms such as Hamilton Microlab STAR, Tecan Fluent, AssayMAP Bravo, Beckman Biomek, or Dynamic Devices Lynx. Ensure QC and reproducibility, including system suitability checks, performance tracking, and SOP documentation. Serve as proteomics point of contact for assigned drug discovery project teams. Collaborate with project leads to define experimental strategy, timelines, and expected results from the proteomics perspective. Communicate study design, progress, and results clearly to cross‑functional team members (chemistry, biology, safety, DMPK, bioinformatics). Demonstrate creativity and apply novel approaches to solving scientific problems. Propose novel and practical ideas, aligned with scientific strategies and demands. Qualifications A Doctoral degree in Chemistry, Biochemistry, Chemical Biology, or a related field is required. 3+ years of proven hands‑on experience operating and troubleshooting LC‑MS systems independently for proteomics (academic core or industry). Experience with label‑free proteomics workflows and robust sample preparation techniques as well as data processing suites Proteome Discoverer, MaxQuant, DIA‑NN, Spectronaut, or Skyline. Excellent interpersonal and communication skills for cross‑functional collaboration and project team engagement. Strong planning and project coordination skills with the ability to handle several projects at a time in a fast‑paced environment. Preferred: planning and performing target deconvolution / targeted protein degradation experiments. Preferred: expertise in PTM enrichment (phospho, ubiquitin, acetyl, glyco). Preferred: familiarity with single‑cell or spatial proteomics workflows. Preferred: industry drug discovery experience. The anticipated base pay range for this position is $109,000 to $174,800. The Company maintains highly competitive, performance‑based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. Subject to the terms of their respective plans, employees and / or eligible dependents are eligible to participate in the following Company-sponsored employee benefit programs: medical, dental, vision, life insurance, short‑ and long‑term disability, business accident insurance, and group legal insurance. Subject to the terms of their respective plans, employees are eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)). Subject to the terms of their respective policies and date of hire, employees are eligible for the following time off benefits: Vacation – 120 hours per calendar year; Sick time – 40 hours per calendar year; for employees who reside in the State of Washington – 56 hours per calendar year; Holiday pay, including Floating Holidays – 13 days per calendar year; Work, Personal and Family Time – up to 40 hours per calendar year; Parental Leave – 480 hours within one year of the birth / adoption / foster care of a child; Condolence Leave – 30 days for an immediate family member, 5 days for an extended family member; Caregiver Leave – 10 days; Volunteer Leave – 4 days; Military Spouse Time‑Off – 80 hours. Additional information can be found through the link below. For additional general information on Company benefits, please go to: The compensation and benefits information set forth in this posting applies to candidates hired in the United States. Candidates hired outside the United States will be eligible for compensation and benefits in accordance with their local market. This job posting is anticipated to close on 12/19/2025. The Company may, however, extend this time‑period, in which case the posting will remain available to accept additional applications. Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via, internal employees contact AskGS to be directed to your accommodation resource. Required Skills: Accelerating Analytical Reasoning, Clinical Data Management, Critical Thinking, Data Analysis, Data Reporting, Data Savvy, Design of Experiments (DOE), Drug Discovery Development, Issue Escalation, Molecular Diagnostics, Pharmaceutical Microbiology, Product Knowledge, Research Proposals, Scientific Research, Standard Operating Procedure (SOP), Technologically Savvy. Preferred Skills: Accelerating Analytical Reasoning, Clinical Data Management, Critical Thinking, Data Analysis, Data Reporting, Data Savvy, Design of Experiments (DOE), Drug Discovery Development, Issue Escalation, Molecular Diagnostics, Pharmaceutical Microbiology, Product Knowledge, Research Proposals, Scientific Research, Standard Operating Procedure (SOP), Technologically Savvy. #J-18808-Ljbffr