Phd Position: Exploring Energy Metabolism On C1

vor 2 Wochen

Wien, Wien, Österreich ACIB - Austrian Centre of Industrial ... Vollzeit

PhD position

Exploring energy metabolism on C1 carbon sources in the yeast _Komagataella phaffii_**
in Vienna / Austria for 30 hours a week

That's the project

  • Komagataella phaffii (Pichia pastoris)_ is a wellknown methylotrophic yeast that can utilize methanol as the sole carbon source for growth and energy harvesting. Methanol as a C1 carbon source has gained attention as C1 carbon sources do not compete with agricultural land use and food production and can be derived from CO thus contributing to the mitigation of atmospheric CO2 levels. To make an impact on the global CO2 household, C1 based processes need to convert methanol into bulk products, such as organic acids. Most of the organic acids originate from the tricarboxylic acid (TCA) cycle. Therefore it is of great importance to understand the role of the TCA cycle during growth on methanol to be able to rewire the metabolism for efficient organic acid production. In this PhD project, we aim to understand the contribution of the TCA cycle to energy formation in addition to methanol dissimilation and how cytosolic NADH is distributed to organelles when cells are grown on methanol. By understanding the energy metabolism on methanol, we want to create a methanolbased platform for organic acid production through rewiring the metabolism for efficient energy harvesting.

That could be your future
You are working in an enjoyable work climate, have numerous possibilities for further education and personal development. You are part of a challenging and helpful work environment full of team spirit and enthusiasm for your job. You expand your expertise and bridge your science to industry.

And not to forget:
You make your research visible and broaden your network

That's important to us


In the best way you have completed a completed Master (or equivalent) in molecular biology, genetics, biotechnology, biochemistry, or similar study.

Research experiences in the following areas would be fine:

  • Strong background in biochemistry, synthetic biology, molecular biology, biotechnology, or related disciplines
  • Excellent skills in spoken and written English, an organized approach with strong attention to detail and good communication skills with ability to work well in teams.

That's what you should know

  • The annual gross salary is EUR 34,500.
This corresponds to a monthly net amount of EUR 1,800 (paid 14 times a year).

  • Start
    :July 2023:
- duration for 3 years

Scientific Contact:

And now it's your turn Give us an idea of who you are.
Of course, we welcome applicants of all sexes (m/w/x), backgrounds and ages.

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