Systems Immunologist

**Be at the forefront of AI-driven precision immunology for drug discovery**:
Immune-mediated diseases affect hundreds of millions of people world-wide, but less than 12% of new drugs reach approval, largely due to insufficient pre-clinical understanding of the complex underlying disease biology.

You will be joining a pre-seed stage techbio company aimed at disrupting drug discovery in the immunology space - by precisely understanding disease biology through iterative, causal discovery starting from realistic primary patient models. Our founders have authored several landmark publications in the precision medicine space, previously exited a precision medicine startup, and built a unique translational research program in a large pharmatech drug discovery company. As natives of both tech and bio spaces we deeply appreciate the unique irreducible challenges that come with both.

Consider joining us if you want to co-create innovative tech that addresses a critical unsolved problem at the root of drug discovery: effectively exploring the causal mechanisms of disease through more realistic models prior to designing therapeutics.

**Your role**:

- Design and perform target discovery and validation experiments to help develop the next generation of I&I drugs.
- Co-develop large-scale screening assays (functional, high content microscopy, multi-omics) as part of a unique lab-in-the-loop AI discovery system.
- Develop screening assays to support early-stage small molecule discovery, from cell engineering and chemical screens, to hit validation studies for hit-to-lead nomination.
- Be part of a flat cross-functional team that deeply appreciates the challenges of each domain and is determined to make a dent.

**Your profile**:

- Ph.D. degree with a focus on systems immunology, cell/molecular biology, or a related field.
- Deep appreciation for reproducibility best practices, e.g. through meticulous recording of experimental parameters in electronic lab notebooks.
- Proficiency with standard molecular biology techniques (e.g. qPCR, western blot).
- Excellent verbal and written communication skills in English (German not required).
- Solution-oriented, persistent systems thinker with a proven track record of translating research into practice.

**Why us?**:

- The opportunity to be part of a pioneering, highly collaborative team with a purpose.
- Healthy participatory culture from the beginning: you will significantly shape company decisions, culture, and strategy.
- A compensation package including salary, benefits, and an early equity stake with substantial long-term upside.

This is optionally a hybrid position requiring a few days per week onsite. The base of operations will be in the Klosterneuburg area on the ISTA campus, roughly 30 minutes outside of Vienna (reachable by bus from Vienna).

**About us**:
Graph is a precision immunology techbio that leverages perturbation modeling from primary patient cell samples combined with multi-omics data to deliver transformative targeted therapies and biomarkers for immune-driven diseases. Graph believes that due to an incomplete understanding of complex immune-mediated diseases, millions of patients are left without adequate treatment options - and AI trained with complex disease data can solve this.