Master’s Student Position

vor 2 Monaten

Wien, Österreich Max Perutz Labs Vienna Vollzeit

We are an internationally competitive, innovative and creative research group investigating fundamental cellular mechanisms in the regulation of gene expression and RNA metabolism by combining genome-wide experiments with cutting edge genetic-, molecular
- and biochemical assays. We are looking for a highly motivated and dedicated master’s student to work on a project aiming to systematically dissect RNA exosome, a key player involved in RNA processing and degradation in the mammalian system.- Open since Sep 23, 2024**About the research project**

Tight control of RNA processing and degradation is a crucial step of post-transcriptional gene regulation. The RNA exosome is an evolutionary conserved, essential, multisubunit protein complex involved in the maturation and/or degradation of most coding and non-coding RNA species. The RNA exosome has been extensively characterized at the structural and functional levels, however our understanding of the assembly, proteostatic control and nuclear import of RNA exosome subunits remain obscure. The advertised project utilizes various protein perturbation techniques (**inducible knockouts**, **degron-approaches**) combined with **flow-cytometry**, **microscopy **and **classical biochemistry** to gain in-depth insights into RNA exosome biology. The project offers the opportunity to acquire a broad range of technical skills and to learn to independently conduct a research project.

**Application**

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