Postdoc for Super-resolution Microscopy of Muscle

vor 4 Monaten

Wien, Österreich Max Perutz Labs Vienna Vollzeit

The Ries lab is developing super-resolution microscopy methods for structural cell biology. As part of an international team in an HFSP-funded project, we will use superresolution microscopy to study the structure and assembly process of z-discs and are looking for a Postdoctoral Researcher with a cell biology background.

**About the position/ the research project**

The overall aim of the project is to investigate how a highly ordered sarcomeric Z-disc structure arises from disordered Z-bodies. The collaborative team will combine expertise in structural biology and modelling (Djinovic, EMBL Grenoble, Oda, University of Tokyo), advanced imaging (Ries, University of Vienna) and cardiovascular development and disease (Hinson, The Jackson Laboratory) and adopt a multifaceted and multiscale approach to tackle the central questions on sarcomere cytoskeleton assembly in biogenesis at the molecular and structural level.

You will use advanced super-resolution microscopy including MINFLUX and automated multi-color 3D SMLM to a) measure the dynamics of essential components and investigate when during maturation the random diffusion is frozen out and permanent interactions and thus order are established, and b) image cytoskeletal components at different time points during sarcomere biogenesis to directly observe the emergence of order.

We are looking for a talented, highly motivated postdoctoral scientist who shares our enthusiasm for pushing the limits of microscopy for biological discovery. You should hold a PhD degree in biology and should have experience in cell and molecular biology techniques and fluorescence microscopy. Experience in super-resolution microscopy and advanced data analysis is beneficial. Training and supervision will be provided throughout the project, but we also expect a high level of drive and independence. Excellent spoken and written English skills are required.

**Application**

**Contact**

Further information about the Ries lab:

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