Phd Thesis “the Blood-brain Barrier in Rare

vor 3 Wochen

Wien, Österreich Austrian Institute of Technology Vollzeit

PhD Thesis “The blood-brain barrier in rare neurodevelopmental diseases”
- Center for Health & Bioresources
- You work on the role of the blood-brain barrier in rare neurodevelopmental diseases such as rasopathies
- You elucidate alterations in blood-brain barrier functionality based on mutations underlying the diseases.
- You investigate the role of the communication between brain endothelial cells and CNS cells such as astrocytes, pericytes and neurons for disease progression and therapeutic approaches.
- You combine high-throughput screening methods and cell culture models based on patient-derived human induced pluripotent stem cells (hiPSC) to evaluate the influence of mutations on the functionality of the blood-brain barrier.
- You implement novel methods to study the relevance of the cellular microenvironment on treatment strategies.
- You study drug transport (small molecules, nanoparticle carriers) under disease conditions.
- You support and supervise master’s students in the lab, write conference contributions and publish results in leading scientific journals
- You unravel changes at the blood-brain barrier in rare neurodevelopmental diseases and develop novel therapies using e.g., cutting edge hiPSC-based cell models and microscopic techniques.
- You are integrated in an interdisciplinary team evaluating in _vitro/in vivo _correlations.

Your qualifications as an
**Ingenious Partner**:

- MSc. in life sciences, e.g., molecular biology, molecular biosciences, molecular medicine, biotechnology, neurosciences, pharmaceutical sciences, or a related field
- Experimental skills in cell culture (preferentially endothelial, epithelial, hiPS cells, fibroblasts), protein chemistry and molecular biology
- Strong sense for responsibility and team spirit
- Excellent communication skills in English

**What to expect**:
EUR 2,464.80 gross per month for 30 hours/week based on the collective agreement. There will be additional company benefits. You will be part of our international AIT PhD community and participate in our AIT PhD framework programme. As a research institution, we are familiar with the supervision and execution of PhD theses, and we are looking forward to supporting you accordingly

**CV, cover letter** and
**certificates** online.

**For further information please contact**:

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