Paid Diploma

vor 2 Monaten

Graz, Österreich Research Center Pharmaceutical Engineering GmbH Vollzeit

Paid Diploma / Master's Thesis
**Influence of the material moisture on a continuous pharmaceutical manufacturing process**
Ref.No DA178

To dedicated students of Chemical Engineering, Pharmaceutical Engineering, Pharmacy or related studies.

**Objective**

In the pharmaceutical industry, a common method for a continuous downstream process of an active pharmaceutical ingredient (API) involves blending the API, either as a powder or liquid, with excipients, followed by hot melt extrusion (HME) of the mixture. The resulting extrudates are then pelletized, mixed with additional excipients, and finally compressed into tablets.

This diploma/master’s thesis will investigate the impact of moisture on the pelletability and tabletability, the material is exposed during this manufacturing process. Therefore, the raw material, the extrudates, and the pellets will be exposed to various levels of moisture and characterized afterwards regarding their quality for pelletability and tabletability.

**Withing the framework of this diploma / master’s thesis we offer the following**:

- Extensive participation in a top-level and industrially relevant research project in an international environment
- Supervised training in the task
- Assistance of experienced staff with the implementation of innovative ideas
- Access to highly modern infrastructure on campus of Graz University of Technology
- Assistance with the publication of results

**Financing**:

- Compensation on the basis of a service contract

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