(Senior) Research Scientist

Vor 4 Tagen

Wien, Österreich Proxygen GmbH Vollzeit

Proxygen’s mission is to harness the most innovative, cutting-edge technologies and know-how to redefine the limits of what is druggable. Most drugs are designed to block one specific function of a disease-causing protein. But over 80% of human proteins are not accessible via this approach and are generally considered “undruggable”. At Proxygen, we specialize in a completely different class of drugs, called molecular glue degraders. These have the unprecedented potential to tackle diseases that have thus far been considered “undruggable”.

Originating from one of the most prestigious research institutions in Europe, our irrevocable focus lies on excellence in everything we do. While being proud to be a truly Viennese company, our team comes from almost all regions of the world - with one common goal in mind: pushing the boundaries of what is druggable.

We are looking for an enthusiastic full-time **(senior) **research scientist** excited to reach this goal together with us and help grow Proxygen to the next level.

**What we are looking for**:

- PhD degree with a focus on molecular oncology, cell/molecular biology, or related disciplines, with a proven scientific track record that includes at least one first author publication.
- Solution-oriented, persistent researcher with an independent, well-structured, and goal-oriented working style.
- Experience in cell line engineering and molecular biology experiments (e.g. cloning, western blot) is required.
- Experience in CRISPR/Cas9 technology, establishment of cell-based reporter assays or chemical screening is preferred.
- Familiarity with targeted protein degradation or the biology of the ubiquitin-proteasome system is desirable.
- Fluency in Python and/or R is a plus.
- Good written and oral communication skills in English are required.
- High accuracy, reliability, and excellent interpersonal and organizational skills.
- Positive attitude, professionalism, and team player mentality.

**What your main responsibilities will be**:

- Developing assays to support early-stage glue degrader discovery, from cell engineering and chemical screens, to hit validation studies for hit-to-lead nomination.
- Executing experiments to inform chemical optimization and definition of target product profile of degraders.
- Collaborating in a multidisciplinary team to develop novel solutions for glue degrader discovery and optimization, and to efficiently advance drug discovery programs.
- Accurate and meticulous recording of work processes and results according to internal documentation practices.
- Providing supervision to team members.
- Contribution to communication/reporting through internal presentations and external presentations with external pharma partnerships.

**What we offer**:

- Cutting edge drug discovery in a state-of-the-art equipped biotech company with a clear focus on pushing the boundaries of the druggable space.
- A young, dynamic, and highly international team that regularly gets together for company events and happy hours.
- Opportunity to get engaged in activities that will shape the future of the company beyond the contribution on R&D level.
- New lab and office infrastructure with supermarkets, and a convenient connection to Vienna’s public transport, all around the corner.
- Flexible work hours.

**Application details**:

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