Master Thesis Opportunity
Vor 4 Tagen
Neurodegenerative diseases like Parkinson's Disease (PD) pose a major challenge to our aging society. At the Hallacli Lab, we study how toxic protein aggregates, especially alpha-synuclein (α-syn), contribute to disease progression. Our recent work has uncovered a novel connection between α-syn and Processing bodies (P-bodies) - RNA granules that play key roles in RNA metabolism (Hallacli , Cell, Our goal is to understand how these ancient structures contribute to α-syn-induced toxicity in neurons and how a-syn modulates RNA metabolism in the cell.
Open since Oct 28, 2025
About the position/ the research project
We currently do not fully understand how α-syn integrates to the human decapping complex and how it modulates its enzymology. This project will aim to reconstitute full or partial human mRNA decapping complex, along with purified α-syn in order to understand the mechanistic details of α-syn-decaping interactions. Your work will include; i) generation of multi-cistronic Baculovirus expression constructs, ii) working with Baculovirus expression systems and expression of full/partial human decapping complex, iii) measuring stoichiometry of human decapping complex by mass photometry, iv) Establishing cross-linking mass-spectrometry to understand protein-protein interactions, v) using AlphaFold models to rationally design point mutants to pinpoint interaction surfaces within the complex.
The ideal Candidate
We are seeking a highly motivated Master's student to join our international research team, where English is the working language. The ideal candidate holds a Bachelor's degree in Molecular Biology, Biochemistry, Chemistry, Biotechnology, or a related field, with strong academic performance. Candidates should have solid experience in molecular cloning and protein purification techniques, excellent organizational skills, meticulous attention to detail, and a commitment to accurate lab documentation. We value a proactive mindset, curiosity about neurodegenerative disease mechanisms, and the ability to work both independently and collaboratively. The position begins with a rotation, with the possibility to continue into the Master's thesis based on successful performance and mutual agreement.
How to apply?
Are you interested? Send your detailed CV along with a motivation letter explaining your background and how you could contribute to
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