Senior Director, Genomics

Overview At Editas Medicine, we are pioneering the possible. Our mission and commitment is to translate the power and potential of the CRISPR/Cas12a and CRISPR/Cas9 genome editing systems into a robust pipeline of medicines for people living with serious diseases around the world. Our goal is to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for a broad class of diseases. At Editas Medicine, we’re a team of passionate problem solvers, harnessing the power and potential of CRISPR gene editing to transform the future of medicine. Driven by a shared purpose to serve people living with serious diseases, we succeed together through collaboration, mutual respect, and innovation. If you want to be part of a team where your voice is heard and respected, where you can operate at the forefront of gene editing, and push the boundaries of what’s possible in medicine, come join us and become an Editor Decoding The Role Editas is seeking a Senior Director of Genomics and Bioinformatics to be a pivotal scientific and strategic leader within our Research & Translational Organization. The individual will provide leadership for the assessment and implementation of advanced genomics and analytical methods crucial for target discovery and for the design and execution of in-silico and experimental strategies that guide our programs from discovery through clinical development. This role will be responsible for the company's strategy for off-target nomination and analysis, a critical component of developing safe and effective CRISPR-based medicines. You will lead a talented team of scientists performing human statistical genetics, computational biology, NGS, in vitro screening, and bioinformatics. As our subject matter expert, you will be responsible for articulating our off-target analysis strategy and data packages to global regulatory agencies. This is a highly cross-functional role that requires a strong partner to our Discovery Research, Nonclinical, Clinical, and Regulatory teams to drive our therapeutic programs forward. Characterizing Your Impact As the Senior Director of Genomics/Informatics, you will: Develop and lead the overarching strategy for off-target nomination and assessment for all therapeutic programs, ensuring cutting-edge, phase-appropriate, and rigorous approaches. Serve as the subject matter expert on off-target analysis for global regulatory submissions (IND, BLA) and agency interactions, clearly and convincingly communicating our strategy and findings. Lead, mentor, and grow a high-performing team of scientists performing NGS, in vitro screening, statistical genetics, and computational biologists and bioinformaticians, fostering a culture of innovation, scientific excellence, and collaboration. Oversee the design, execution, and analysis of large-scale Next-Generation Sequencing (NGS) datasets to identify and characterize potential on- and off-target editing events. Drive the evaluation and implementation of novel computational tools, algorithms, and machine learning models to continuously improve the precision and efficiency of our genomic analyses. Partner closely with discovery, nonclinical, regulatory and clinical teams to integrate genomic insights, guide experimental design, and inform program decisions. Author and review relevant sections of regulatory documents and scientific publications, ensuring clarity, accuracy, and strategic alignment. The Ideal Transcript To thrive in this role, you’ll need: A PhD in Computational Biology, Bioinformatics, Genomics, or a related scientific field. 12+ years of progressive experience in the biotech or pharmaceutical industry, with a demonstrated record of leading bioinformatics or computational biology functions. Deep expertise in gene editing (CRISPR preferred) and a proven track record of developing and implementing strategies for off-target analysis. Significant experience contributing to the genomics components of regulatory submissions (e.g., IND, BLA) and a strong understanding of health authority expectations. Extensive experience in the analysis and interpretation of large-scale NGS datasets (e.g., WGS, GUIDE-seq, etc.). Proficiency with relevant programming languages (e.g., Python, R) and bioinformatics tools in a cloud computing environment. Outstanding communication and presentation skills, with a demonstrated ability to articulate complex scientific and regulatory concepts to diverse audiences. Fundamentals That Set You Apart A visionary and strategic leader with the ability to inspire and develop a team of highly skilled scientists. Exceptional problem-solving skills and the ability to translate complex biological questions into robust, integrated analytical strategies. A highly collaborative and influential leader capable of building strong relationships and driving alignment across a matrixed organization. Direct experience interacting with regulatory agencies (e.g., FDA, EMA) on topics related to gene editing safety and off-target analysis is strongly preferred. Benefits and Compensation Editas provides a comprehensive array of benefits to all employees, including a Blue Cross Blue Shield PPO Medical Plan, a company-funded Health Savings