Bioinformatician (F/m/d) in Bioinformatics Core Unit

vor 5 Monaten

Wien, Österreich St. Anna Kinderkrebsforschung Vollzeit

**Location**:
**Research group**:
**Working hours**:

- Vienna
- Bioinformatics Core Unit- full-time

As a bioinformatician, you will conduct analyses of genomics data from childhood /adult cancers, hereditary diseases and cancer predisposition syndromes in close collaboration with molecular biologists, geneticists, pediatric oncologists and other bioinformaticians. Examples of recent projects include the development of bioinformatic algorithms based on long-read panel sequencing technology for diagnostic approaches as well as genomic, transcriptomic and epigenomic analyses of pediatric leukemia and solid tumors on primary tumors and liquid biopsies, and the analysis of experimental model systems (e.g. Shahin T et al _Science Immunology_ 2021; Halbritter et al _Cancer Discovery_ 2019; Peneder P*, Stütz AM* et al _Nature Communications_ 2021; Popitsch et al _Bioinformatics_ 2021 and Schinnerl et al _Haematologica_ 2019). The research institute St. Anna CCRI is also involved in several large-scale national and international research collaborations and serves as a national reference center for several clinical trials.

The position is focused on acting as a new active member in the young and dynamic bioinformatics core unit and as service provider for the different research groups at St. Anna CCRI but also offers opportunities for independent and applied research of novel bioinformatics methodologies related to the St. Anna CCRI research programs.

**Your responsibilities**:

- You will lead bioinformatics design and analyses of ”omics” datasets (bulk/ single-cell RNA sequencing, ATAC-seq, ChIP-seq,) and integration with other data sources as required
- You will provide bioinformatics support to different research groups at St. Anna CCRI as well as diagnostic groups at Labdia and provide guidance/supervision to group-associated bioinformaticians
- You will evaluate new open-source and commercial software packages for analysis, annotation, and interpretation of sequencing and cytogenomic data, and integrate with existing bioinformatics and genomics databases including in-house developed pipelines
- You will document all procedures, reliably and actively communicate results to other bioinformaticians, researchers, the diagnostic teams and clinicians
- You will keep up-to-date with current developments in the field, contribute ideas and help in designing novel cutting-edge genomics projects and diagnostic approaches

**Your profile**:

- Master's or PhD degree or proven track record in bioinformatics, computational biology or data analysis
- Strong interest in cancer genomics and applied research; background in molecular genetics is of advantage
- Experience in applied NGS data analysis such as transcriptomics (RNA-seq, scRNA-seq), panel sequencing (RNA, DNA, liquid biopsies), Whole Exome/Genome sequencing (WES/WGS), long-read sequencing (e.g. Oxford Nanopore) and Epigenomics (WGBS, ChIP-seq, ATAC-seq); additional experience with other omics methods is a plus
- Demonstrable experience in programming languages required for data analysis (R and/or Python); experience with other programming languages is of advantage
- Proficiency with Linux/Unix; experience with HPC is of advantage
- Experience in building and maintaining bioinformatics tools/pipelines; experience with scientific and/or diagnostic software development is of advantage
- A solid foundation in statistics
- Ability to work independently, self-motivated and creatively
- Excellent communication skills in English with the ability to communicate effectively at different levels of technical knowledge

**Our offer**:

- A meaningful, inspiring, and international environment
- An outstanding working atmosphere in a strong team with excellent research and development opportunities, find more info on Kununu and Glassdoor
- Access to state-of-the-art infrastructure
- Flexible working hours, possibility of working from home, discounted lunch and other great benefits
- Great location in the center of Vienna, a capital of biomedical research in Europe with excellent quality of life A fair and attractive salary package starting at € 3.275,
- gross (14x per year, full-time basis) depending on your qualification and experience

**Who we are**:
The St. Anna Children's Cancer Research Institute (St. Anna CCRI) is located in the heart of Vienna, the most livable city in the world and one of the most important sites for biomedical research in Europe. St. Anna CCRI is a multidisciplinary and internationally networked center of excellence whose goal is to contribute to a sustainable improvement in the cure rates of childhood and adolescent cancers through innovative research and development. Due to the close cooperation between clinic and research, St. Anna Children's Cancer Research offers the ideal environment for cutting-edge research at a high international level and its implementation in clinical practice.

St. Anna CCRI is an equal opportunity employer. We value

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