Master's Thesis: joining Rna Molecules with

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Wien, Österreich Max F. Perutz Laboratories Vollzeit

**About the project**:
We know the composition of the pentameric tRNA ligase complex, its three-dimensional structure (partially) and the biochemistry of RTCB, its catalytic subunit; however, the function of the other subunits and their isoforms remain unknown. We have also identified Archease, a co-factor that turns the tRNA ligase complex into a multiple turnover enzyme (Popow et al. 2014, Nature). Archease is “unfaithful” to the ligase by binding to another proteinWhat is the importance of that interaction?

You will have the opportunity to solve these mysteries - and eventually others - by mastering molecular biology, biochemistry and structural biology. You will be working in a vibrant and creative lab atmosphere, and will be trained to think critically, and write and communicate your results and ideas in a professional way

**Application and contact**:



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