Master Student in Tumor Immunology
vor 2 Monaten
The Project
Your tasks in this position will include:
- Cell culture techniques, such as differentiation and transduction of myeloid cells
- Molecular biology techniques, such as cloning and lentiviral transduction
- Flow cytometry and cell sorting
- Isolation of primary immune cells from different tissues, e.g. tumor, bone marrow, etc (mouse, human)
- Option for training in basic mouse handling
After receiving the appropriate training, the new Master student will independently carry out experiments. In addition, the new group member will be a part of individual as well as group meetings to deepen their understanding of the background and current scientific directions in the field of tumor immunology and cancer immunotherapy.
Your Profile
- Currently pursuing a Msc degree in life sciences
- Eager to join a young team and be trained in new techniques
- Strong interest in the field of tumor immunology
- Experience with basic molecular biology (e.g. cloning and PCR)
- Excellent written and oral communication skills in English
- High accuracy, reliability and independence, able to work seamlessly in a team
The Maier Lab
Our group is studying interactions within the microenvironment of solid tumors that cause immune-suppression and tumor immune evasion. Our overall aim is to understand and break through limitations of current immunotherapies. We want to develop novel immunotherapy concepts by modulating and reprogramming specific immune cell compartments to achieve optimal immunity against tumors. Questions that fuel our research are: How can we empower antigen-presenting cells to prime effective tumor-directed T cell responses? What antigen-presenting cell phenotypes play a role in T cell polarization and restimulation at the tumor site and how do they drive/limit T cell exhaustion? What factors drive T cell exhaustion in the tumor microenvironment and the draining lymph node? What specific pathways need to be targeted in tumor-associated myeloid cells to break their immune-suppressive properties? To achieve our goals, we combine cell-culture based high-throughput technologies with mechanistic in vivo studies, single-cell transcriptomics and immune-profiling of patient-derived tumor material.
The Principal Investigator
Barbara Maier studied molecular biology at the University of Vienna and obtained her PhD from MedUni Vienna, working on deciphering the role of type I interferon in pulmonary inflammation under the mentorship of Professor Sylvia Knapp. She focused on bacterial infections in the lung and peritoneum and the protective or detrimental roles of inflammatory mediators therein. She then continued her training as a postdoctoral fellow in the laboratory of Professor Miriam Merad at the Icahn School of Medicine at Mount Sinai in New York (USA). There, she gained extensive knowledge of human tumor immunology and myeloid components of tumor immune suppression. In her main work, she uncovered a regulatory module expressed in dendritic cells in human non-small-cell lung cancer patients, functionally validated multiple of these regulatory molecules, and showed that modulating the regulatory program in dendritic cells leads to improved tumor control. Barbara Maier joined CeMM as a principal investigator in January 2021. Her lab focuses on tumor immunology and specifically on the dynamics of antigen-presenting cell/T-cell interactions in the tumor microenvironment and tumor-draining lymph nodes and how tumor-associated antigen-presenting cell phenotypes shape tumor-directed T-cell responses. Barbara Maier is a recipient of the the prestigious ERC Starting Grant for the year 2023.
About the Institute
We offer
- Work within an experienced, interdisciplinary, and international team at one of Austria’s leading research institutes
- Ample opportunities to contribute and gain experience in a key area of biomedical research and precision medicine
- An inspiring workplace with an international setting, strong team spirit, and an excellent work climate
- A wide range of social, cultural, and sports activities organized by the institute
- Excellent employee benefits including full insurance coverage (health, accident, retirement), health care services, subsidized cafeteria
- Monthly gross salary of EUR 1.299,60 for 20 hours/ week (following the recommendations of FWF)
- Support for relocating to Vienna is provided (relocation reimbursement, visa support, etc.)
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