Master Thesis in Mucosal Immunology
vor 2 Monaten
We are recruiting an ambitious _master thesis student_ who wants to pursue groundbreaking research in the areas of mucosal immunology. It will be based in the laboratory of Clarissa Campbell at the _CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences in Vienna_._
The Project
Gut bacteria produce short chain fatty acids (SCFA) from the fermentation of dietary fibers. Acetate, propionate, butyrate and other SCFA shape the differentiation and function of mucosal CD4+ T cells at the steady state by directly affecting cellular metabolism, engaging G-coupled receptors and modulating HDAC activity. Infection with intestinal helminths increases SCFA levels and attenuates the pathophysiology of extra-intestinal inflammatory diseases; however, whether the SCFA-HDAC axis contributes to regulate CD4+ T cells responses in this context remains unknown. The project will assess the HDAC-dependent effects of SCFA on the differentiation and stability of Th2, Treg and Th9 cells in primary T cells flow cytometry, RNA-sequencing and proteomics as readouts. The project will also test whether changes in SCFA levels during helminthic infection exert HDAC-dependent effects on intestinal T cell immunity and host resistance. The student will have the opportunity to learn intestinal immune cell isolation protocols and carry out live propagation of helminths. Altogether, the proposed work will explore the role of HDACs as key T cell targets for microbial metabolites and shed light on how changes in microbial metabolism may affect T cell immunity during infection.
We are looking for an outstanding Master student with a strong background in immunology with a minimum time commitment of 8 to 12 months to study how microbial metabolites affect the intestinal immune system during infection. Cell culture expertise is required, and flow cytometry experience highly desirable. We provide the opportunity to work on cutting-edge research in a highly supportive environment, with significant chances for contributing to an important scientific publication.
The Campbell Lab
We are a highly collaborative team. We enjoy curiosity-driven research (_what if_ ?) and want to shift paradigms in biology. We believe that understanding commensal microbes is the key to understanding our own physiology. The team includes: 1 PI (Clarissa, she/her, BRA), 1 Lab Manager (Elena, she/her, MKD), 1 PhD student (Jagoda, she/her, POL), 1 guest scientist (Taras, he/him, UKR) and one Postdoc (Max, he/him, AUT). We combine microbial engineering, synthetic biology, animal models, transcriptional and metabolic profiling and flow cytometry to address the following questions: How do gut bacteria respond to food intake? What metabolites do they produce? How does our immune system interpret these metabolites? What is the impact of microbiota-derived metabolites and systemic metabolic changes on physiology during health and disease? We are also excited to be the first group to set up a gnotobiotic husbandry operation in Austria.
The Principal Investigator
Clarissa Campbell joined CeMM as a principal investigator in July 2021. She studied biology with a minor in genetics at the Federal University of Rio de Janeiro (UFRJ) and subsequently earned a master’s degree from the Oswaldo Cruz Foundation (FIOCRUZ), investigating how bacterial molecules exert immunomodulatory effects on mammalian cells via nuclear receptors, a topic she would continue to explore throughout her career. She joined the Tri-Institutional Immunology and Microbial Pathogenesis Program at Weill Cornell Medical College in New York as a graduate student where she specialized in mucosal immunology and regulatory T (Treg) cell biology. After obtaining her PhD, Clarissa Campbell remained under the mentorship of Dr. Alexander Rudensky at Memorial Sloan Kettering Cancer Center to continue her work on host-commensal interactions and pursue broader scientific questions bridging the fields of immunology and metabolism. Her research has characterized a circuit whereby microbial metabolites including short-chain fatty acids and secondary bile acids facilitate the differentiation of peripherally induced Treg cells, which in turn suppress immune responses to colonization and preserve a niche for a group of intestinal bacteria. More recently, she found that a bile acid sensing nuclear receptor contributes to the cell-intrinsic responsiveness of effector T cells to fasting. Her lab is interested in investigating how changes in microbial and organismal metabolism contribute to regulating immune-cell function. She is the recipient of the 2023 FEBS excellence award and is part of the FWF SFB HIT- HDAC modulation in T cells (2023) and the FWF Cluster of Excellence Microbes for the planet (2023).
About the Institute
The mission of CeMM is to achieve maximum scientific innovation in molecular medicine to improve healthcare. At CeMM, an international and creative team of scientists and medical doctors
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