Master’s Thesis

vor 1 Woche

Wien, Österreich Max Perutz Labs Vienna Vollzeit

Neurodegenerative diseases like **Parkinson’s Disease (PD)** pose a major challenge to our aging society. At the Hallacli Lab, we study how toxic protein aggregates, especially **alpha-synuclein (α-syn)**, contribute to disease progression.
- Open since Aug 11, 2025

**Introduction to the Lab**

Our recent work has uncovered a novel connection between α-syn and **Processing bodies (P-bodies)** - RNA granules that play key roles in RNA metabolism (Hallacli et.al, Cell, 2022). We aim to understand how these structures contribute to α-syn-induced toxicity and how **RNA granules interact with lipid membranes** in both healthy and diseased neurons.

**About the position / the research project**

Building on our previous discoveries, this project investigates how **α-syn overexpression disrupts RNA-binding protein (RBP) function**.

**Your work will include**:
- Using a **dual fluorescent reporter technology developed in our lab** to measure protein perturbation in a systematic and high-throughput manner.- Performing **flow cytometry** as a readout- Generating and screening **stable cell lines** for RBP-α-syn interactions- Validating findings in **HEK293** and/or **iPSC-derived human neurons**

We are looking for a **highly motivated** Master’s student with:
- A Bachelor’s degree in Molecular Biology, Biochemistry, Neuroscience, or related fields, with **strong** academic performance- Strong experience in human cell culture and molecular biology techniques (e.g., cloning, RNA techniques, Western blotting, microscopy)- Familiarity with or interest in **high-throughput screening** and flow cytometry**Excellent** organizational skills, attention to detail, and accurate lab documentation- A **proactive mindset**, curiosity for neurodegenerative disease mechanisms, and ability to work independently and collaboratively- Prior research experience and knowledge of **RNA biology, bioinformatics, or stem cell work**are a plus.

The position begins with a rotation, with continuation into the Master’s thesis contingent on successful performance and mutual agreement.

**Application Requirements**- CV- Motivation Letter- 1-2 Letters of Recommendation

Position start date: November 2025

**Contact**

Elizabeth Ethier

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