Master’s Thesis
Vor 2 Tagen
The goal of the Master project will be to elucidate the mechanism(s) by which the ISR kinases PERK, HRI and GCN2 specifically recruit eIF2. The project will involve recombinant protein purification, quantitative biochemistry and structural biology.
- Open since Jan 09, 2025
**About the Leonard lab**
The Leonard lab investigates the mechanisms by which signals are transduced in the cell into appropriate downstream effects. The post-translational modification of proteins with a single phosphate group, a process called phosphorylation, is a ubiquitous signaling mechanism that governs the flow of this information. We are interested in the mechanisms that govern the addition of phosphate groups by KINASES, their removal by PHOSPHATASES, and the structural and functional consequences of these modifications. We use a wide variety of biochemical, biophysical and structural biology tools, complemented with cell biology, to explore how cells regulate the transmission of information at the molecular level with high fidelity in both space and time. More information can be found on the Leonard lab group page.
**About the Master thesis project**
Cells must be able to cope with all manner of insults and stressful environments in order to survive. Stress signals, including nutrient starvation, viral infection, and heme deficiency, are sensed by the integrated stress response (ISR) kinases. The ISR kinases converge on a single substrate, the eukaryotic initiation factor 2 (eIF2), phosphorylating it to elicit a global shutdown in translation, thereby allowing cells time to recover. Whilst a mechanistic understanding of how the ISR kinases phosphorylate eIF2 to inhibit translation initiation is already quite advanced, it is not currently understood how each of the ISR kinases recruits eIF2 in order to drive efficient and specific phosphorylation. The goal of the Master project will be to elucidate the mechanism(s) by which the ISR kinases PERK, HRI and GCN2 specifically recruit eIF2. The project will involve recombinant protein purification, quantitative biochemistry and structural biology.- Hold a Bachelor’s degree in biochemistry, chemistry or molecular biology- Have practical experience in molecular biology- Have excellent communication and organisation skills and a teamwork spirit
**We are looking for someone**- who is excited by science- who is fascinated by molecular mechanisms- who is creative, critical, and communicative- can work independently in a supportive team
**Application
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