Laboratory Technician in Vascular Heterogeneity

Vor 6 Tagen

Wien, Österreich CeMM Vollzeit

The laboratory of Laura de Rooij at CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences in Vienna, is seeking a highly motivated Laboratory Technician to join an international team working at the intersection of vascular and endothelial cell diversity, single-cell omics, and human aging/pathology. The lab is specifically interested in investigating the transcriptomic make-up and function of endothelial cells across human organs and tissues, using a combination of cutting-edge omics technologies, clinical samples, and in vitro model systems.

We are looking for a Laboratory Technician with a strong background in vascular biology, cell and molecular biology, or related fields. You will be responsible for lab organization and management, and you will contribute with your technical skills and research experience to the success of the research group. In addition, you will be a part of individual as well as group meetings to deepen the understanding of the ongoing scientific directions in the group. We provide the opportunity to be part of cutting-edge research projects in a highly supportive environment, with a time commitment of 18-24 months and with the potential for co-authorship in a high-impact publication. The preferred start date for this position is April or May.

**Profile**:

- Degree in life sciences (BSc, MSc, Mag, DI) or equivalent training (e.g., HBLVA Rosensteingasse)
- Qualified laboratory experience in molecular and cellular biology and/or angiogenesis assays
- Experience in (endothelial) cell culture techniques is essential
- Familiarity with 3D cell culture (e.g. vessel/organ-on-chip), and/or human induced pluripotent stem cells is highly desirable
- Experience with human sample handling, multiplexed histology, and/or single-cell RNA-sequencing is a plus
- Excellent written and oral communication skills in German and English, excellent organizational skills
- High accuracy and reliability, able to work seamlessly in a dynamic and young team

Your tasks
- Laboratory management and organization, ordering of laboratory consumables
- Molecular biology, such as preparation of single cell RNA-sequencing libraries
- Cell culture, using 2D, 3D and/or microfluidics-based assays
- Cell isolation and sorting of primary human (endothelial) cells
- Functional vascular assays, such as migration or spheroid sprouting
- Immunofluorescence staining of cell cultures and/or human biopsy material
- Phenotyping of endothelial cells using multicolour flow cytometry

The Laura de Rooij Laboratory

The goal of the Laura de Rooij laboratory is to study the gene expression landscape of the vascular endothelium, one cell at a time. Utilizing advanced single-cell RNA sequencing technologies, our lab is dedicated to mapping the diverse landscape of endothelial cell heterogeneity across various organs, tissues, pathological conditions, and throughout the aging process. Through this comprehensive approach, we seek to uncover novel genes and molecular pathways linked to vascular aging and disease. The major lines of current research in the lab involve healthy human aging, cellular senescence, and liver cirrhosis.

The Principal Investigator

Laura de Rooij studied biomedical sciences at the University of Amsterdam (The Netherlands). She then joined the Stem Cell and Cancer Research Institute at McMaster University in Hamilton (Canada), where she studied the role of RNA-binding proteins in leukemic stem cells via an in vivo two-step CRISPR-Cas9-mediated screening approach. For her postdoctoral studies, she returned to Europe to work under the mentorship of Professor Carmeliet in the lab of Angiogenesis and Vascular Metabolism at VIB-KU Leuven (Belgium). There, she led and contributed to numerous single-cell transcriptome atlases of endothelial cells, generated from a diverse range of tissues, preclinical models, and clinical patient material in health and disease. Her studies have shed new light on the degree of vessel subtype heterogeneity in different tissues, as well as the altered composition and rewired molecular circuitries of endothelial cell subtypes in disease. Moreover, her efforts led to the discovery of previously unknown vascular subtypes and functions, including endothelial cells with a lipid-processing phenotype and potential prognostic relevance in breast cancer, and endothelial cells with a putative profibrotic function in COVID-19. Laura de Rooij joined CeMM as principal investigator in September 2022. Since then, her lab focuses on deciphering the transcriptomic landscape and the role of endothelial cells in human health, aging, and pathology.

Previously, Laura received numerous prestigious grants and awards, including an FWO Postdoctoral Fellowship (2020-2022, Belgium), a Lorne F. Lambier, Q.C. Scholarship (2015-2016, Canada), and a Young talent award (2014-2017, Prins Bernhard Cultuurfonds, the Netherlands). Since starting the lab, she moreover received independent fundin

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