Master’s Thesis

vor 3 Monaten

Wien, Österreich Max Perutz Labs Vienna Vollzeit

The goal of the Master project will be to reconstitute the functional signaling unit of TBK1 and mechanistically dissect its activation by upstream signals, such as damaged mitochondria or intracellular pathogens. The project will involve recombinant protein purification, quantitative biochemistry and structural biology.- Open since Sep 16, 2024**About the Leonard lab**

**About the Master thesis project**

Cells degrade and recycle damaged intracellular organelles, dangerous intracellular pathogens, and toxic protein aggregates by autophagy. All of these processes are united by the orchestrated decoration of the cargo with a ubiquitin coat. TBK1 (TANK-binding kinase 1) controls the process of autophagosome formation in mitophagy, xenophagy and aggrephagy by signaling the presence of the ubiquitinated cargo and controlling the downstream assembly of the autophagic machinery. The mechanisms by which TBK1 is activated downstream, however, remain poorly understood.- Hold a Bachelor’s degree in biochemistry, chemistry or molecular biology-
- Have practical experience in molecular biology-
- Have excellent communication and organisation skills and a teamwork spirit**We are looking for someone**- who is excited by science-
- who is fascinated by molecular mechanisms-
- who is creative, critical, and communicative-
- can work independently in a supportive team**Application

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