Master’s Thesis Project

Vor 4 Tagen

Wien, Österreich Max Perutz Labs Vienna Vollzeit

The Karagöz Lab combines cell biology with bottom-up reconstitution to dissect cellular protein-quality control pathways. Our team consists of a group of talented PhD and Master students and research technicians working on diverse topics to reveal how cells respond to proteotoxic stress.
- Open since Dec 16, 2024

**About the project**

Perturbations to endoplasmic reticulum (ER) homeostasis activate highly conserved signaling cascades called the unfolded protein response (UPR). While several ER chaperones were proposed to regulate the activation and deactivation of the UPR signaling, we lack mechanistic and functional insights into those interactions. We seek a highly motivated Master’s Student interested in structural and biophysical approaches to reveal how ER chaperones regulate the UPR.

To answer these open questions, you will use NMR spectroscopy and other biophysical methods to uncover the nature of the interactions between the UPR sensors and chaperones and their functional consequences. You will work in a team with PhD student Grzegorz Ścibisz, who has extensive structural biology and biochemistry expertise and has established fundamental steps toward the project.- Learn recombinant protein expression and purification- Set up assays to study protein-protein interactions- Learn to set up NMR spectroscopy experiments and analyze the data

**Required Skills**:
- Basic knowledge in biochemistry, structural biology, and molecular biology- Motivation to learn and establish assays and methods- Fluency in English and good communication skills

**Application**

The position is **open from March 1, 2025**. An initial contract will be for nine months or a year with the possibility of extension if required.

**Contact**

For further details, please do not hesitate to contact Elif Karagöz

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