Master Student in Magnetic Bioprinting
vor 1 Woche
We are recruiting an ambitious _master thesis student_ who wants to pursue groundbreaking research in the areas of bioengineering. It will be based in the laboratory of Abdel Rahman Abdel Fattah at _CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences in Vienna_._
The Project
Organoid research has revolutionized our ability to model human tissue in vitro, but variability between organoids often limits their reproducibility and the complexity of biological phenomena they can recapitulate. This project introduces a novel bioprinting approach to enhance cortical organoid (CO) organization using a high-throughput, label-free, and nozzle-free magnetic bioprinting technique. By depositing differentiated human pluripotent stem cells (hPSCs) layer-by-layer, we aim to construct COs with pre-defined cortical layers. This bioprinting approach seeks to reduce organoid variability by controlling initial cellular organization, offering an innovative alternative to traditional self-organization methods.
We will optimize magnetic field geometries and cell magnetophoresis through simulations with COMSOL and Matlab. We will build a magnetic platform using in-house 3D-printers, generate magnetic fields using N52 neodymium magnets, and synthesize paramagnetic media using gadopentetic acid. Using differentiated hPSC-reporter lines, we will generate PAX6+, TBR1+, CTIP2+ and SATB2+ cells, which we will bioprint in a multilayered fashion to form our organoids. We will use entropy-based metrics to quantify tissue organization and study the organoids’ ability to maintain spatial order. Our project will also assess the transcriptomic landscape of bioprinted organoids using single-cell RNA sequencing, shedding light on molecular players that improve tissue organization. This work has broad implications, from tissue engineering to drug screening and regenerative medicine, and promises to establish a new bioprinting paradigm for organoid research.
Your Profile
We are seeking a motivated and talented Master’s student with a strong background in bioengineering, cell biology, or related fields. Experience in cell culture techniques is essential, and familiarity with organoid culture, matrices and/or hydrogels, microscopy, or computational modeling is highly desirable.You will have the opportunity to contribute to cutting-edge research in a highly collaborative environment (working closely with a Postdoc) and gain expertise in bioprinting, organoid technologies, and transcriptomic analysis. The project requires a commitment of 6-12 months, with the potential for co-authorship in a high-impact publication.
The Abdel Fattah Lab
Our lab exists at the interface of engineering and biology and we are driven by the question: how do cells use the extracellular matrix and mechanical forces to collectively coordinate, initiate, and maintain tissue organization, and what happens when forces are too much to handle? We particularly focus on how local mechanical conditions instruct tissue organization through global morphological and cell state changes, but also tissue disorganization in conditions such as liver fibrosis and traumatic brain injuries. We take three approaches to address this (1) we engineer our own platforms to mechanically stimulate and measure local and emerging mechanical properties in tissues, (2) we explore mechanobiology across the scales in-vitro, going from multicellular events to molecular drivers, in order to characterize and study the dynamic relationship between cells and their extracellular matrix (ECM) microenvironment, (3) we develop computational models to explore the physical laws and logic used by cells to organize, in our effort to establish the mechanical roadmap to tissue organization. In our quest to answer these questions we use magnetic and fluid/solid mechanics engineering principles to build tools that allow us to locally mechanically stimulate cells, deliver traumatic injuries as well as measure local mechanics. Next we focus on quantifying multicellular dynamic cell-ECM interactions using a combination of time-lapse microscopy, high content image analysis, and neighborhood analyses. We explore the driving molecular programs that drive these interactions by combining transcriptomics with mechanical data in mechano-transcriptomics maps. Finally, we describe the organization strategies employed by cells from a mechanical standpoint through computational models using positional information, cellular automata and reaction diffusion models.
Our main research topics include central nervous system health, traumatic brain and spinal cord injuries, and liver fibrosis. We utilize several in-vitro model systems, with a primary focus on those derived from human pluripotent stem cells. Our team is composed of 1 Principal Investigator (Abdel), 2 Postdocs (Dunja and Sowmya), 1 Research Technician (Sabrina),).
The Principal Investigator
About the Institute
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